This article is part of a Bridgespan Group research project that focuses on a new wave of district-led "innovation zones" that holds promise to overcome the challenges of turning around failing schools and deliver significant improvements in student outcomes. This new wave provides a subset of district schools with control over staffing, curriculum, and budgeting. Such autonomy often is guaranteed by a contractual agreement and enabled by state law that can sustain the zone despite potential changes in district leadership. The schools are sometimes operated by a nonprofit that is held accountable to the school district for significant improvement in student outcomes. The research highlights the experiences of five school districts that are vanguards of this new wave of innovation zones--Chicago; Denver; Indianapolis; Memphis, Tennessee; and Springfield, Massachusetts. These innovation zones reveal certain design features that place a focus on improving teaching and learning over multiple years--the heart of any successful turnaround effort. Specifically promising innovation zones: (1) set ambitious goals; (2) guarantee autonomy; (3) improve teaching and learning; (4) follow the students; and (5) are sustainable, scalable, and built to last. The article looks in detail at Shelby County (Memphis) public schools' innovation zone--the iZone. Unlike the majority of district-led efforts to turnaround schools, the iZone in Memphis has produced strong results, gaining national attention in the process. [For the full report on all five school district innovation zones, "School District Innovation Zones: A New Wave of District-Led Efforts to Improve Economic Mobility," see ED582407.]