The new large-scale assessments rolled out by consortia and states are designed to measure student achievement of rigorous college- and career-ready (CCR) standards. Recent surveys of teachers in several states indicate that students with disabilities like many features of the new assessments, but that there also are challenges. This Brief was prepared to provide information and suggestions for state education agencies (SEAs) and other technical assistance (TA) providers who work with local education agencies (LEAs). It highlights four main challenges identified by the teachers, and then addresses the implications for instruction, the relationship to CCR standards, and the implications for TA providers. Though this Brief is focused on the immediate needs of students with disabilities, many of the identified issues apply to all learners. It is organized to allow the implications to be easily shared with teachers in a way that can support their development of new knowledge, skills, and practices.