Despite high Electronic Health Record (EHR) system adoption rates by hospital and office-based practices, many users remain highly dissatisfied with the current state of EHRs. Sub-optimal EHR usability as a result of insufficient incorporation of User-Centered Design (UCD) approach during System Development Life Cycle process (SDLC) is considered as a leading factor for this observed discrepancy. The purpose of this study is to expand our knowledge around physicians' interaction with in-patient EHRs around clinical documentation work flow processes by examining various tasks related to not entry and related information-seeking. The knowledge gained could be applied in tailoring physicians' EHR training and designing a future EHR leading to more efficient and effective task performances, ultimately resulting in greater user satisfaction and enhanced EHR usability. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]