This chapter provides an overview of the Interactive Strategy Tutor for Active Reading and Thinking-2 (iSTART-2). iSTART-2 is a game-based tutoring system designed to improve students' reading comprehension skills. It does so by providing them with instruction on how to self-explain using comprehension strategies. In this chapter, we first discuss why reading comprehension is a critical skill and how the iSTART-2 system addresses the development of this skill through the instruction of five comprehension strategies. Second, we provide an overview of the iSTART-2 system and its features. Third, we discuss the need for this reading comprehension technology in the classroom and provide a general overview of how iSTART-2 addresses those needs as well as the Common Core State Standards. Fourth, we describe previous findings from research using the various iterations of the iSTART-2 program. Finally, we describe how iSTART-2 can be accessed by teachers and used within classroom environments. [This chapter was published in: S. A. Crossley & D.S. McNamara (Eds.) "Adaptive educational technologies for literacy instruction" (pp.104-121). New York: Taylor & Francis.]