Historically Black Colleges and Universities (HBCUs) continue to strive for academic relevance in spite of the national problem of the misalignment of mission and values among their institutional leadership. The national problem was important to both the HBCU institutions and the entire academic community to establish global relevancy. The institutional challenges faced by these entities include strategic growth, fund development, and accreditation sustainment. The purpose of this mixed methods with a case study design was to identify the overall national phenomenon at regionally selected HBCUs and to understand and explore the dynamics of the misalignment of values and mission among presidential leaders, their administrative staff and faculty stakeholders in relation to their influence on campus stability and growth. The conceptual framework was used to arouse research and to extend knowledge. The application of the relationship theory was used to explore the misalignment relationship of leadership styles of HBCU presidents, institutional stakeholder perception and the mission of their schools aided in understanding the phenomenon. A correlational statistical analysis of the misalignment relationship between the Multifactor Leadership Questionnaire-5x (MLQ-5x) sub-categories of perceived leadership styles in percentages and the teleconference interviews with HBCU presidents identified insight into the impact of the research phenomenon. Qualitative data was analyzed by identified interpretive themes and patterns from the interviews. Quantitative data was analyzed in tables to recognize quantifiable behavior patterns. The results revealed a misalignment between the perceived leadership styles of the president and their stakeholders related to the mission and values of their institution. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]