According to the National Institutes of Health, "Translational research includes …the process of applying discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans… [and] research aimed at enhancing the adoption of best practices in the community. Following this tradition, this paper defines translational research in the Social-Behavioral-Educational (SBE) sciences as the recursive, bidirectional process of integrating scientific knowledge and research-based discoveries into community and societal practices and policies. Because there is a woeful lack of understanding about the science of translation, or how this very difficult work happens. Little is actually known about the strategies, structures, and processes of translational research that influence the capability and probability of diverse researchers from distinct disciplines collaborating effectively to solve significant social, behavioral, educational, and mental health problems. Barriers such as discipline-centric terminologies, traditional methodological approaches, time constraints, and narrowly conceived and executed dissemination strategies are significant. To accelerate the transmission of knowledge across the spectrum of theory, experimentation, implementation and diffusion, an augmented translational research approach specific to the SBE sciences is needed. The specific aims of this initiative are two-fold. First, the initiative will uncover various aspects (phases and processes) of translation that are most effective in addressing a range of significant social, behavioral, educational and mental health challenges plaguing society. Second, the knowledge gained about the science of translation will be applied to ameliorate specific social, behavioral, educational, and mental health problems by targeting specific substantive issues in these areas that impede individual, familial, social, and societal health. Through advanced understanding of the mechanisms by which meaningful integration of researchers from multiple disciplines and across the basic, applied, community and policy spectrum occurs, translational researchers will provide critical core support to augment the efficient translation around targeted SBE research. Relatedly, structures developed as a product of this initiative will serve as a hub to inform significant training, practice and policy advances among researchers in the SBE sciences. [Development of this white paper was completed with partial support from the University of Nebraska-Lincoln Office of Research and Economic Development (ORED).]