San Francisco's Mission Promise Neighborhood (MPN) is a federally-funded Promise Neighborhood initiative that supports community-based organizations, schools, and other public agencies to work in defined neighborhoods and build integrated supports for children and youth from cradle to college and career. Since 2013, the Gardner Center has partnered with MPN to support implementation and ongoing assessment of the initiative. This report draws on perspectives from school principals, family engagement staff, teachers, and community partners regarding the ways in which implementation of MPN supports has advanced the initiative's goals. Specifically considered are the following key programmatic and operational components of the MPN model: 1) the efforts to support strategic coordination of school-level supports and school-community partnerships by promoting collaborative leadership; 2) the resources of a Community School Coordinator and a Family Success Coach (FSC), and 3) the integrated academic, social, emotional, and health supports at each focus school. Interviews probed for contextual factors that mediate achievement of goals as well as other ongoing challenges and areas for improvement. Student achievement and behavioral data drawn from the administrative records of the San Francisco Unified School District (SFUSD) as well as MPN survey data were incorporated in the assessment. The object of this research is to draw lessons to support continuous improvement and scale-up efforts, and to inform policymakers and other researchers interested in Promise Neighborhood strategies across the country. [The authors would like to thank and acknowledge the contributions of the following individuals to this study: Maureen Carew, Denise Geraci, Cristina Lash, Tie Liang, Nancy Mancini, Erica Messner, Leslie Patron, and Nikki Tognozzi. We would also like to express appreciation for our partners at the Mission Economic Development Agency, San Francisco Unified School District, and the school leaders, staff, MPN partners, and families who supported this work and have been generous with their time, knowledge and perspectives.]