When the number of college access and success organizations in St. Louis, Missouri, began to grow, some leaders began noticing that organizations were not coordinating their services to reach students; rather, they were developing a tendency toward competition for limited financial resources. Student-focused organizations have the ability to increase the impact of their services by using partnerships and collaborations synergistically. As college access and success initiatives grow, organizations face new and often daunting opportunities to combine their expertise. This case study will examine the lessons learned by the Wyman Center and The Scholarship Foundation of St. Louis as they teamed up with university partners for a new college persistence program.