Opportunities abound for software designers and developers to create impactful tools for teachers, school leaders, students, and their families. This guide for developers, startups, and entrepreneurs addresses key questions about the education ecosystem and highlights critical needs and opportunities to develop digital tools and apps for learning. Crowd-sourced from knowledgeable educators, developers, and researchers who were willing to share what they have learned, this guide is designed to help entrepreneurs apply technology in smart ways to solve persistent problems in education. Ten opportunities for technology to transform teaching & learning are detailed: (1) Improving mastery of academic skills; (2) Developing skills to promote lifelong learning; (3) Increasing family engagement; (4) Planning for future education opportunities; (5) Designing effective assessments; (6) Improving educator professional development; (7) Improving educator productivity; (8) Making learning accessible to all students; (9) Closing opportunity gaps; and (10) Closing achievement gaps.