The current study examined the differential validity of the SAT for predicting cumulative GPA (cGPA) through the second year of college by college major, as well as the differential prediction of cGPA by college major across student subgroups. The relationship between the SAT and cGPA varied somewhat by major, as well as by major and subgroup (e.g. gender, ethnicity,and parental education level). This variability was likely due to differences in the nature of the college course work,grading practices, student self-selection, and academic cultures (e.g., male dominated or highly competitive) across majors. The findings from this study may be particularly relevant to colleges and universities in examining different admission criteria for acceptance to specialized colleges and major programs within an institution, and thus it could serve as a comprehensive resource for higher education researchers examining college major and performance. Supplemental tables are appended.