The Urban Institute conducted an implementation and participant-outcomes evaluation of the Alaska Native Science & Engineering Program (ANSEP). ANSEP is a multi-stage initiative designed to prepare and support Alaska Native students from middle school through graduate school to succeed in science, technology, engineering, and math (STEM) careers. ANSEP offers intensive academic support, exposure to industry, and the opportunity to participate in a learning community incorporating Alaska Native cultural identity. In addition to supporting individual students, the ANSEP model is also designed to effect systemic change to improve the climate for Alaska Natives in the Alaska kindergarten through 12th grade (K-12) educational system, the University of Alaska, and Alaska's STEM industries. This document provides an overview of the major takeaways from the evaluation project. The findings inform ANSEP's programming and provide lessons for other STEM education programs that serve underrepresented minorities nationwide. [This project was funded by The Alaska Native Science & Engineering Program (ANSEP).]