Health information technology has become more prevalent in hospitals, physician offices, clinics, and other areas of medical treatment, especially since the federal government passed legislation to offer incentive payments for the meaningful use of electronic health records (EHRs). Previous research demonstrated a decrease in medical errors as well as a decrease in overall healthcare costs when EHRs were used. Registered nurses represent one population that has been pressured to utilize the EHR, has suffered stress during the process, and was forced to adapt to the challenges inherent with installation of the software, ongoing updates to hardware and software, and multiple changes in work flow, often without any feedback into the activities that directly affected them. This experimental, quantitative research examined the effect of technostress creators and inhibitors on the perceived productivity of oncology nurses as they used an EHR to increase the safety, quality, and effectiveness of healthcare for patients with cancer. A total of 228 nurses who gave direct care to patients and used an EHR for that care provided responses to the survey. Of that number, only three were in the experimental group and completed the continuing education intervention, which was significantly below the required sample size. Therefore, this intervention was not analyzed. Of the remaining respondents, 112 nurses between the ages of 18 and 65 met the criteria for the control group and completed the survey. Multivariate linear regression showed an inverse relationship between productivity and the technostress creators and inhibitors. As technostress increased, the nurse's perceived productivity decreased. As technostress decreased, the nurse's perceived productivity increased. Age and level of nursing education were analyzed yet were not significant predictors of productivity. Other demographic data was collected and may be utilized in future research. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]