Millions of Americans suffer from chronic physical illness. The U.S.-Mexico border region has significantly higher rates of infectious and communicable diseases than other areas of the nation. The purpose of this study was to assess the effects of a comprehensive culturally relevant health risk prevention program on Hispanic youth and their families. The results indicated highly significant improvement in emotional competence, self-control, social competence, behavioral awareness, and learning skills of the fifth grade participants. Additionally, as a result of the prevention program, the parents and caregivers of the target youth demonstrated significant improvement in their knowledge of health and safety issues.