Virtually no formal treatment protocol exists for the health/mental health care of biracial Filipino Amerasians in the Philippines. Today this large group comprises a mostly socioeconomically at risk diaspora. A recent 3-year study found depression, elevated anxiety, joblessness, social isolation, substance and alcohol abuse, and housing insecurity, often traits among refugee and immigrants. An innovative social work practice course for the treatment of these core mental health issues for undergraduate students, originated at Systems Plus College Foundation, Angeles, Pampanga, Luzon, presents the knowledge needed for effective intervention strategies.