Institutions of Higher Education are challenged to educate an increasing, diverse ethnic minority population. This study examines (1) if the theory of the Big Five personality traits as a predictor of the cultural intelligence theoretical model remains constant with ethnic minority college students attending a southeastern United States Historically Black College or University, and (2) if there is a predictive relationship between cultural intelligence and the psychological well-being of ethnic minority college students. Ethnic minority college students received an online survey that included demographic questions, the Cultural Intelligence Scale (Earley & Ang, 2003), Goldberg's (1999) Internal Personality Item Pool (IPIP), an alternate version of Costa and McCrae's (1992) commercial Neuroticism, Extraversion, and Openness Personality Inventory (NEO-PI-R™), and the Scale of Psychological Well-Being (Ryff, 1989). Standard multiple regression analyses were used. The results indicate that the antecedent relationship between the Big Five personality traits and the cultural intelligence model remained constant. Study results did not demonstrate a significant relationship between minority college students' cultural intelligence and psychological well-being. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]