This paper presents the annual report of the National Math and Science Initiative (NMSI) for 2008. Eighteen months ago, the National Math and Science Initiative did not exist. Today NMSI is helping lead the country forward in math and science. In just 18 months, NMSI has rolled out the first round of grants and has implemented programs in 14 vanguard states. In 2007, NMSI awarded grants of $13.2 each to non-profits in six states to institute AP Training and Incentive programs and grants of $2.4 million to 13 institutions of higher learning for the replication of the UTeach training program for math and science teachers. These programs are essential to address two of the country's most pressing challenges: (1) Getting more American students to master the math and science knowledge that is crucial in today's high-tech economy; and (2) Training more teachers in math and science content so they can inspire and equip the next generation to succeed. Advanced Placement Training and Incentive Programs are now operating in these six states: Alabama, Arkansas, Connecticut, Kentucky, Massachusetts, and Virginia. Thanks to those programs, more than 13,000 students are now enrolled in more challenging math, science and English classes in 67 schools. Enrollment in AP programs has increased nearly 70 percent in those schools thanks to NMSI grants. The UTeach program for math and science teachers has been implemented in 13 universities. Originated at The University of Texas at Austin, the UTeach program equips students majoring in math, science or computer science to receive full teaching certification without adding time or cost to their degree. UTeach teachers, who often serve in schools with a low-income student population, foster scientific and numeric literacy in children, which prepares them to function in a society that is increasingly dependent on science and technology. Appended are: (1) Advanced Placement Progress Report; and (2) UTeach Report.