Policy and program decisions typically involve selecting one choice from among a set of options, and research about the effect of those options can help inform the decision process. However, for the research to be useful, decision makers need a way of drawing accurate lessons from what often can be a large assortment of relevant studies. Systematic reviews can be particularly useful in this process because they identify, assess, and synthesize key pieces of evidence on policy or program effectiveness. This brief provides recommendations for conducting high quality systematic reviews. We hope that the recommendations will increase the number of such reviews, to provide decision makers with a greater number of useful evidence summaries that can inform decision making.