Primary schools can play a significant preventative role in addressing drug-related harm in young people's lives. "One and All" is a programme aimed at assisting schools to plan and implement drug prevention in the middle primary years through developing students' social and emotional competence and nurturing their resilience. It is part of a larger collection of multimedia resources, REDI--Resilience Education and Drug Information, that focuses on preventing and reducing harm associated with drugs by fostering resilience in students and their school communities. This booklet is intended for primary school Principals, the school executive, and staff. It provides background information on recent research that has informed "One and All" and provides advice on where further information can be found to support schools in providing effective drug prevention in the middle primary years. A bibliography is included. (Contains 2 resources.)