It may seem that deaf-blindness refers to a total inability to see or hear. However, in reality deaf-blindness is a condition in which the combination of hearing and visual losses in children cause "such severe communication and other develop mental and educational needs that they cannot be accommodated in special education programs solely for children with deafness or children with blindness" (34 CFR 300.8 (c) (2), 2006) or multiple disabilities. Children who are called deaf-blind are singled out educationally because impairments of sight and hearing require thoughtful and unique educational approaches in order to ensure that children with this disability have the opportunity to reach their full potential. This paper answers the following questions: (1) Who is deaf-blind, and what are the causes of deaf-blindness?; (2) What are the challenges facing person who is deaf-blind?; (3) What are the particular challenges facing the family, teachers and caregivers of a person who is deaf-blind?; and (4) What help is available for families, caregivers and teachers of children and adults who are deaf-blind?