This paper presents the rules and guidelines of the Intel International Science and Engineering Fair 2011 to be held in Los Angeles, California in May 8-13, 2011. In addition to providing the rules of competition, these rules and guidelines for conducting research were developed to facilitate the following: (1) protect the rights and welfare of the student researcher and human subjects; (2) protect the health and well-being of vertebrate animal subjects; (3) follow federal regulations governing research; (4) offer guidance to affiliated fairs; (5) use safe laboratory practices; and (6) address environmental concerns. [This guide was created by the Society for Science & the Public.]