The Wingspread Conference Series (2003-2005), "Strategies to Strengthen the Relationship between Higher Education and Society", brought together scholars, institutional and national leaders, community activists, and graduate and undergraduate students to examine the current and evolving relationships between higher education and society. The goals of this annual series included (a) assessing the status of efforts and challenges focused on strengthening American higher education's civic and social responsibility to society, and (b) developing focused strategies and commitments among leaders to advance higher education's civic and social role. This monograph, "Taking Responsibility: A Call for Higher Education's Engagement in a Society of Complex Global Challenges", is a culmination of writing and reflective dialogues between leaders at the summative Wingspread conference in October 2005. This monograph contains the following papers: (1) The Paradox of Higher Education Leaders Working toward Educational Equity: Three Frameworks for Conceptualizing Higher Education for the Public Good (Penny A. Pasque); (2) Regrouping, Rethinking, and Redirecting Energies Around Higher Education for the Public Good: A Keynote Address (Suzanne Morse); (3) Higher Education Has Done Well, We Can Do More: A Report from the Wingspread Access, Equity and Social Justice Committee (Lesley A. Rex); (4) Fulfilling Higher Education's Promise: Addressing Social Issues in the 21st Century (Adrianna Kezar); (5) The Paradox of Immigration Policy and Higher Education Access: State Responses to Federal Immigration Policy (Jose L. Santos); (6) A Discussion of Fair Market Possibilities for the Public Good (Deron Boyles, Alisa F. Cunningham, Rasheedah Mullings, and Penny A. Pasque); and (7) The Changing Role of Public Higher Education in Service to the Public Good (John C. Burkhardt). An introduction by John C. Burkhardt and Jamie Merisotis is included. Individual papers contain tables, figures, footnotes, and references.