This report is the based on a 10-year study of the activities developed under a National Science Foundation (NSF) Louis Stokes Alliance for Minority Participation (LSAMP) grant to a collaborative of institutions from the State University of New York. The goals of LSAMP are to recruit and retain under-represented minority students in the STEM (Science, Technology, Engineering, and Mathematics) disciplines and encourage these students, as appropriate, to apply to and enter graduate programs in the sciences. The study used a logic model, considering resources, activities, and outcomes. The report provides details of major strategies adopted by the alliance and in each area summarizes what the evaluation and research found were best practices leading to success. The areas identified were: local organizational arrangements to administer the grant; undergraduate research; academic support; process skills needed in college; social support and community building; interest in graduate school; and success in graduate school. In each area, the conclusions are based on data and analysis obtained from surveys, site visits, interviews, focus groups, and observations of meetings. The study also reviews relevant literature, providing additional documentation for conclusions and recommendations. Student voices are heard in numerous quotes and a comprehensive survey (N = 82) asking about adjustment to and progress in college. The report will be useful to anyone involved with programs that support students in higher education. The best practices contain guidelines for implementation and show the connections between program activities and student success. (Contains 5 tables.)