The purpose of this study was to examine the viability and principle design methodologies of Mobile Learning models in developing regions. Demographic and market studies were utilized to determine the viability of M-Learning delivery as well as best uses for such technologies and methods given socioeconomic and political conditions within the target regions. Amongst markets and population segments where M-Learning case studies had been conducted, analysis of learning methodologies used to support those programs is also presented here. It is concluded that while technical challenges such as hardware limitations and mobile network infrastructure development present obstacles to the expansion of M-Learning in developing regions, the proliferation of mobile device ownership, rapidly improving mobile technology and consumer cost considerations make M-Learning delivery an increasingly viable and effective choice for new learners in regions where such opportunities were scarcely available previously. A bibliography is included.