CDC's Marketing and Communication Strategy Branch (MCSB) in the National Center for Health Marketings Division of Health Communication and Marketing divides audiences into segments with similar needs, preferences, and characteristics and provides CDC programs with audience-specific information, marketing expertise, and communication planning. To develop "Audience Insights", secondary data is collected and analyzed from CDC-licensed consumer databases, books, articles, and the Internet. "Audience Insights" can help readers to communicate more effectively with their audience in order to influence their behavior. This issue of Audience Insights provides insights into how teens think and how their health behaviors reflect their economic, racial, gender, and geographic disparities. Ideas for effective communication with them are also offered.