Understanding the structure and function of proteins is an important part of the standards-based science curriculum. Proteins serve vital roles within the cell and malfunctions in protein self assembly are implicated in degenerative diseases. Experience indicates that this topic is a difficult one for many students. We have found that the concept of protein self assembly can be effectively demonstrated using a hands on investigative laboratory exercise and readily available resources. Complete methods and student guide will be presented so you can start protein synthesis right away! Appended are: (1) A Student Guide; and (2) Application Questions.