The Comprehensive Partnerships for Mathematics and Science Achievement (CPMSA) is a National Science Foundation program launched in 1993, designed to improve the mathematics and science education of urban students in medium-sized cities. The goals of the program, in addition to increased enrollments in mathematics and science classes, were to improve student achievement, teacher knowledge and skills, and to enhance student interest in mathematics and science careers. As the program matured, the focus shifted to standards-based curriculum, instruction, assessment, and professional development. This report highlights the achievements of the program overall and presents case studies of five selected CPMSA sites: (1) Omaha, Nebraska; (2) Jackson, Michigan; (3) Laredo, Texas; Oakland, California; and (5) Montgomery, Alabama. Data were collected from a variety of sources. Findings show that the primary goal of increasing the enrollment and successful completion of college preparatory mathematics and science courses was accomplished. Other measures of achievement also showed positive results; 12 of 17 sites with available data showed improvement in the percentage of students passing the fourth-grade mathematics test. Disparities in achievement and achievement gaps between white and minority students were narrowed. Details are provided about program success in each of the case study cities. An appendix describes overall student outcomes in 26 exhibits. (Contains 4 tables, 72 figures, and 65 references.) (SLD)