This article presents specific, practical information to guide mental health counselors in treating individuals who meet the criteria for panic disorder. It delineates the specific strategies identified in the research literature for use by mental health counselors. Full resolution of panic attacks by one form of treatment may not always be possible and based on current outcome research, a combined psychopharmacological and cognitive-behavioral approach is recommended. Although the prescription of pharmacological treatment for panic disorder is outside the scope of practice for the mental health counselors, knowledge and understanding of effective drug therapy is necessary and an extensive description is included of the most common drugs used. Cognitive and behavioral therapies have been found to be effective; research has focused on the efficacy of some combination of cognitive restructuring; focused cognitive therapy; panic education; guided imaginal coping; breathing retraining and respiratory control; interceptive exposure therapy; and panic inoculation. Several of these approaches are explained in this article. More research is suggested on the efficacy of specific combinations of interventions in the treatment of panic disorder. (Contains 116 references.) (JDM)