This guide provides a detailed look at the biological basis of drug addiction, examining how the brain and its reward system work and how drug abuse can cause fundamental changes in the way the brain works. It is a resource for clinicians and practitioners. The first section of the guide provides an outline of the following basic concepts presented in the videotape: (1) the electrochemical transmission system of the brain; (2) the effects of drugs on neurotransmission and on the brain's reward system; (3) two types of pharmacotherapy; and (4) approaches to treatment. The second section is a synopsis of the 26-minute videotape. The third section provides a glossary of technical terms. Section 4 provides discussion questions, and section 5 provides an annotated bibliography of resources on drug abuse and the brain. (JBJ)