This guide, which was written by Colorado educators, is intended to help other educators in Colorado weave academic content standards regarding science, assessments, and school-to-career methods into an integrated, comprehensive strategy for preparing all students to meet their future goals. The introduction discusses the guide's purpose, the role of standards and assessments in the context of a changing workplace, the Colorado School-to-Career Partnership, and the guide's structure and content. Section 1 presents the Colorado General Workplace Competencies, which describe the skills and knowledge needed for school and career success and which are organized into the following categories: communication; organization; thinking; technology; and worker qualities. Section 2 offers guidelines for helping special populations of students meet academic content standards while participating in school-to-career opportunities. Section 3 features 18 integration matrices and 18 classroom activities for integrating science standards with workplace competencies. One matrix and one activity are provided for each standard for students in grades K-4, 5-8, and 9-12. Section 4 presents three sample rubrics that are aligned with the integrated learning activities contained in Section 3 and designed to assess the skills and knowledge of students in grades K-4, 5-8, and 9-12. The addresses of Colorado's six school-to-career regional resource centers are listed. (MN)