The trend to internationalize has impacted upon most higher education institutions in the United States. This paper offers an organizational framework for understanding and implementing internationalization as an institution-wide process. The first section of the paper discusses and identifies the core characteristics required for all internationalization efforts, including institutional commitment to internationalization; organizational leadership; and having the necessary resources. The next section discusses and offers micro examples of internationalization of three types of on-campus activities: (1) university services (e.g., student services, information technology/management); (2) curriculum development (individual course development, language courses, infusion, area studies, cross-cultural and international courses, and global studies); and (3) social events (cultural activities, cross-cultural discussions, residence hall activities, and student involvement). A final section of the paper looks at the macro perspective of internationalization, exploring four types of relationships: recruitment of international students; increasing study abroad educational opportunities for both students and faculty; having student and faculty exchange programs; and encouraging international collaborative research programs. (Contains 114 references.) (MKA)