This manual provides information and suggestions about supporting at-risk youth in Colorado and how to enhance their learning. It provides a framework for working with at-risk youth, but its objectives and strategies can be modified as conditions and needs change. The first section provides an overview of at-risk youth in the new millennium, and the second depicts strategies and programs for at-risk youth around the world. These target specific groups of at-risk youth, including those of limited English proficiency, members of minority groups, and other disadvantaged youth. The third section discusses the importance of schools, families, communities, and businesses working together to serve at-risk youth. The fourth section explores the ways in which safe learning environments are paramount to student success, and section 5 provides professional development presentation materials and resources that support at-risk youth. Appendixes include a discussion of how to make standards work, of how to bring out the best of in all students, a grade specific guide for parents, a list of Colorado charter schools, information on career centers, electronic resources, Colorado General Workplace Competencies, resource mapping information, and transition internet resources. (Contains 187 references.) (SLD)