This guide provides information on and materials for implementation of the various school-to-work opportunities available to South Carolina students that combine classroom instruction with structured learning at the work site. An introduction provides a school-to-work vision statement, lists of its benefits and components, descriptions of such opportunities, and answers to common questions about these opportunities. Sections 2-7 each focus on one of the following school-to-work opportunities: registered and youth apprenticeships, cooperative education, internship, service learning, shadowing, and mentoring. Each section provides an overview of the opportunity and information on implementation that includes most or all of the following components: definition, purpose, requirements, strategies for implementation, student and employer benefits and responsibilities, technical assistance, credentials, wages, transportation, time commitment, insurance, regulations, and sample forms. Section 8 presents limited information for these additional school-to-work opportunities in which some school districts may participate: supervised agricultural experience, coordinated co-ops, part-time work, school-based enterprises training plan, and personal mentoring. (YLB)