This paper describes the use of distance learning capabilities to augment and amplify the learning opportunities for part-time graduate students at George Mason University. The students in the biochemistry course described meet periodically on campus for brief interactions with the instructor and peer classmates. Between these synchronous interactions, the class World Wide Web site supports: (1) ongoing asynchronous small group interactions with the professor, peer groups, and other scientists through online discussion groups, e-mail, and listserv facilities; (2) hypermedia presentations on key concepts, developed for and often by the class, and available online for review or correlation to lecture notes; and (3) imaging and audio interactions offering advanced representations of molecular structures, using tools that provide a dynamic and easily updated capability beyond material available in the text. Topics discussed include: the rapidly growing importance of biochemical knowledge; the course objective; the course background, including the nature of the students served, instructional advantages of the Internet format, and the metabolism visualization component of the course; and user viewing tools, including molecular imaging software (RasMol, Chime, MAGE) and database browsing and querying software. Two figures illustrate the class home page and Chime Image views of the tryptophan amino acid molecule. Contains 11 references. (Author/DLS)