This activities-based handbook is designed to assist both mentors and mentees in colleges and universities in developing a relationship that is respectful, meaningful, and fulfilling. It defines the terms associated with the mentoring process and discusses how knowledge of self is critical to developing a successful mentor-mentee relationship. The handbook outlines the role of mentors and mentees, and also provides sets of empowerment activities for each phase of the mentor-mentee relationship, and tips for strengthening the role of mentors and mentees. It includes answers to commonly asked questions about mentoring and ideas for organizational support for the mentoring process. A discussion of gender and minority issues relevant to mentoring is also included. The handbook also reports the results of a study on the mentor-mentee relationship among participants in the University of Northern Colorado McNair Scholars Program. Suggested readings and resources are included. (Contains 23 references.) (MDM)