This book is a compilation of articles from the The American Biology Teacher journal that present biology labs that are safe, simple, dependable, economic, and diverse. Each activity can be used alone or as a starting point for helping students design follow-up experiments for in-depth study on a particular topic. Students must make keen observations, form hypotheses, design experiments, interpret data, and communicate the results and conclusions. The experiments are organized into broad topics: (1) Cell and Molecular Biology; (2) Microbes and Fungi; (3) Plants; (4) Animals; and (5) Evolution and Ecology. There are a total of 34 experiments and activities with teacher background information provided for each. Topics include slime molds, DNA isolation techniques, urine tests, thin layer chromatography, and metal adsorption. (DDR)