This brochure describes the different types of barriers individuals with mobility impairments, blindness, low vision, hearing impairments, and specific learning disabilities face in providing computer input, interpreting output, and reading documentation. The adaptive hardware and software that has been developed to provide functional alternatives to standard operations are described. For individuals with mobility impairments, adaptive hardware and software include changing the positioning of equipment, left- and right-handed keyboards, expanded keyboards, mini-keyboards, keyboard emulation, and voice input. For individuals with blindness, Braille input devices are available as well as voice output, refreshable Braille displays, and scanners with optical character recognition. Individuals with low vision can use large print keytop labels, equipment that modifies display or printer output, and optical character recognition scanners. Advanced speech synthesizers can help those with hearing and/or speech impairments. Individuals with specific learning disabilities can use educational software that provides multi-sensory experiences, interaction, positive reinforcement, individualized instruction, and repetition for skill building. The word processing capabilities of the computer can also help students with dysgraphia. Resources for finding more information about adaptive technology and the DO-IT (Disabilities Opportunities Internetworking Technology) program are listed. (CR)