Despite recent increased attention to Asperger's Syndrome (AS), few psychometric investigations of subjects have appeared and few studies have examined how clinicians and educators might better address the needs of this unique group of people. A diagnosis of AS according to the "Diagnostic and Statistical Manual of Mental Disorders" requires impairment of social interaction, repetitive and stereotyped patterns of behavior, but no clinically significant delay in language or cognitive development. This case report examines in detail the assessment of an inner-city adolescent black male with this syndrome and relates his difficulties to probable compromise of the right frontal (nondominant) lobe. Vocational recommendations were made for this student based on the assessment of his abilities and the recognition of his social limitations. Issues pertaining to future research and educational and vocational planning are discussed. More is known about autism than AS, and this is particularly true among the lower socioeconomic classes. Although AS is related to high functioning autism (HFA), more research is recommended on the practical, clinical implications of diagnosis of AS over HFA. (Contains 1 table, 1 figure, and 44 references.) (Author/SLD)