This report addresses the barriers college students with disabilities face in the laboratory setting. In engineering, mathematics, and science education most courses require laboratory work which may pose challenges to those with disabilities. Instructors should be aware of the individual needs of students with disabilities and make necessary accommodations. The legal requirements on accessibility are reviewed in both the Rehabilitation Act of 1973 and the Americans with Disabilities Act. Services for students with disabilities that may be available at postsecondary institutions are explained. The characteristics that should be considered for the design of innovative tools or for modifying existing equipment in the laboratory settings are examined. Factors are highlighted that should be considered before the modification of laboratories. The design and production of a disability-accessible Computer Assisted Design/Computer Assisted Mathematics station are described and illustrated. An appendix lists 25 sites on the World Wide Web for helping students with disabilities in the areas of science, mathematics, and engineering. A second appendix lists 12 assistive technology sources. (CR)