Curriculum infusion makes a new topic an integral part of an existing curriculum, integrating it into subject areas throughout the curriculum over time. In a tobacco, alcohol, and other drug infusion curriculum, examples might include: discussing alcohol-related themes as they arise in literature, evaluating tobacco statistics in math, studying the effects of cocaine on the brain in science, exploring practices in advertising tobacco in language arts, and even including these topics incidentally in grammar exercises, typing skills practice, or math word problems. This manual, designed to provide support for either a subject-area infusion approach or a thematically-based integrated curriculum approach, is divided into five discipline areas: language arts, social sciences, math and science, physical education, and the arts. Each section begins with a story illustrating how tobacco, alcohol, and other drug education are infused into that subject area. Icons representing important components of successful tobacco, alcohol, and other drug related education are used to indicate which component is being addressed by a particular idea. The components are: (1) factual support, (2) effective decision making skills, (3) support systems and protection, (4) critical thinking and evaluation skills, and (5) positive self-image and peer relationships. Finally, each chapter has an idea section with some ready to use lesson plans. A "Resources" section provides factual information for teachers on these topics: alcohol; how to help children from alcoholic families; teacher intervention in alcohol and other drug abuse problems; marijuana; cocaine and crack; steroids; and systems of drug classification. (Contains 19 references.) (ND)