This manual was developed in conjunction with the implementation of the Colorado Effective Education Model, a systems change project designed to develop best educational practices for students with severe disabilities in inclusive settings. The manual presents adaptations to better meet secondary level students' goals and objectives and describes processes for identifying student outcomes within the context of regular education curriculum/activities. Introductory sections offer general guidelines for designing curricular adaptations to enhance learners' participation and level of mastery, and offer guidelines for designing noncurricular adaptations in the environment, materials, assistance, and presentation. A decision-making framework for using adaptations is provided, followed by a case study applying the framework. A chart then lists curricular outcomes, activities, basic proficiencies, and adaptations in the areas of: (1) English/language arts (communications/basic composition, American literature, poetry, and world literature); (2) social studies (current events and family living); (3) science (life science and ecology); (4) Spanish; (5) mathematics (basic math and geometry); (6) theater; (7) computer keyboarding; (8) choir; (9) weightlifting; (10) world geography; (11) media production; and (12) daily preparation. (JDD)