Growing Up Strong (GUS) is a curriculum designed to develop strong mental and physical health in kindergarten through sixth grade students, with the objective of preventing subsequent substance abuse. This document contains a teacher's guide for using GUS in fifth and sixth grade classrooms (GUS 5-6) and duplication masters of materials that can be sent home with children to promote family involvement in GUS. Part I of the five-part teacher's guide provides background information about the program; the trademark cartoon characters Gus, Gussie, and their friends; GUS's multicultural approach and comprehensive prevention philosophy; and major components of the GUS 5-6 program and accessory materials. Part II includes information on using GUS, evaluating the program, and using the family involvement messages; and a sample message to families. Part III offers suggestions on classroom management and details classroom activities designed to reinforce refusal skills and activities designed to help children develop social and self-management skills. These activities relate to such topics as problem solving, brainstorming, cooperative learning, drug facts, life skills, and stress management. The materials designed for children to take home include information sheets for parents on accepting their children's friends, being a good role model, encouraging physical fitness habits, using techniques of stress management, giving accurate information about drugs, and daydreaming. Part IV provides lists of resources: 28 children's books, 24 books on cooperative learning for teachers, 4 publications for parents, and 31 organizational resources. Sample awards for children, information about drugs, an examination to test children's knowledge about drug facts, and GUS promotional materials are attached. (AC)