A content-based curriculum in English as a Second Language (ESL) focusing on prenatal self-care is presented. The course was designed as a solution to the problem of inadequate prenatal care for limited-English-proficient Mexican immigrant women. The first three sections offer background information on and discussion of (1) content-based ESL instruction, including related methods, rationale, its use in different academic settings, issues in implementation, and adaptation to adult education; (2) the health needs of Mexican women, including cultural and practical barriers to use of health care and health services, and benefits of prenatal care; and (3) the rationale for and design of prenatal care instruction through content-based ESL, including educational benefits, materials, other prenatal care resources, adapting materials for content-based instruction, and design issues. The curriculum itself is then presented. It consists of lesson plans and 44 student handouts on these topics: the body, the fetus, going to the doctor, nutrition during pregnancy, giving birth, and well-baby care. Notes for the instructor and ideas for vocabulary exercises are included. A 100-item list of content and methodological resources is appended. (MSE) (Adjunct ERIC Clearinghouse on Literacy Education)