The purpose of this guide is to amplify the specific issues concerning substance abuse which Head Start grantees need to address, and to suggest resources and strategies to respond to these issues. The guide consists of five chapters, a bibliography, and two appendixes. An introduction (chapter I) discusses the problem of substance abuse and the importance of developing strategies to address this problem within the framework and resources of the existing Head Start program. It is emphasized that strong collaboration must exist between Head Start and other community programs and agencies. Chapter II addresses issues related to Head Start staff, including the staff's role in addressing substance abuse, staff training, development of strategies and policies, and employee assistance programs. Chapters III and IV discuss Head Start's role in helping children and their families affected by substance abuse. Issues include the identification of affected and at-risk children and families with substance abuse problems, approaches to prevention, the adaptation of existing curricula, referral and follow-up procedures, and approaches for special family populations, includent migrant worker Native American, immigrant, and homeless families. The importance of community partnerships is addressed in Chapter V, with specific reference to: (1) how Head Start grantees can link up effectively with other community resources; and (2) what kinds of services and programs are available in communities. A list of resources appears at the end of each chapter. Appended are a bibliography of 17 references; a list of commonly abused substances, their street names, and their effects; and an extensive list of national, regional, and state resources. (GLR)