This paper discusses how "The Ladies' Home Journal" was used by its editor, Edward Bok, in his crusade for food and drug regulation in the United States between the years 1890 and 1906, and whether these efforts were influential in bringing about the Pure Food and Drug Act of 1906. The first section describes "The Ladies' Home Journal's" crusade against the patent medicine industry--the magazine banned the industry's advertising and published a series of articles exposing the dangers of the products and the unethical sales practices employed by the manufacturers of these products. The following section examines the effectiveness of "The Journal's" campaign, finding that its primary contributions were: (1) the precedent set by its advertising ban; (2) its efforts against "Mrs. Winslow's Soothing Syrup" label, causing a more informative label and eventually leading to the elimination of morphine as an ingredient; (3) the creation of awareness in its readers, and encouragement to take action; and (4) its contribution to President Theodore Roosevelt's awareness of the issue. The third section examines other influences in the food and drug regulation campaign, arguing that it was the efforts of "The Ladies' Home Journal," combined with a plurality of other efforts, which eventually brought about the much-sought-after legislation. One hundred and two notes are included. (SR)