Topics addressed in this report were suggested at a meeting of staff from the National Center for Health Services Research and Health Care Technology Assessment (NCHSR) and other Public Health Service representatives held in 1988 to update the Public Health Service's plan for the prevention and control of human immunodeficiency virus (HIV). Current epidemiologic and economic information about Acquired Immune Deficiency Syndrome (AIDS) and other HIV-related illnesses is reviewed, highlighting the complexity of issues and gaps in knowledge that should be addressed in grant research. Priority research issues and examples of substantive research questions are presented. Issues are identified that extend beyond health economics and the costs and financing of services. Researchable topics are outlined with respect to health status measures and information systems, access and barriers to care, quality of care, health systems analysis, cost effectiveness of alternative service and organizational strategies, and provider issues. A general description of application procedures and a bibliography of relevant information are also provided. (NB)