This guide explains ways in which the computer can be used in the science classroom and laboratory. Further, it suggests many resources that can be tapped to help teachers initiate and improve their own programs. Chapters include: (1) "The Computer as a Tool for Student Inquiry"; (2) "The Computer as a Tool for Teachers"; (3) "The Computer as an Instructor"; (4) "Hardware Recommendations"; and (5) "Glossary." The appendices include examples of commercial microcomputer based laboratory (MBL) products; four MBL activities for earth science, biology, chemistry and physics; sources of MBL products; and an MBL bibliography. (YP)