The document describes Lowe's syndrome, a hereditary condition that affects only males and is typically diagnosed during the first year of life. Effects of Lowe's syndrome on the eyes (cataracts, glaucoma, corneal degeneration, and strabismus) are discussed, as well as related problems with the central nervous system, muscles, kidneys, bones, and teeth. Special health concerns arising from these effects include metabolic imbalance, respiratory illness, and constipation. Additional topics addressed in the guide are prognosis, related information on genetics (including females as carriers and genetic counseling), ongoing research efforts, developmental and educational programming, and family dynamics. The booklet concludes with a brief description of Lowe's Syndrome Association, a nonprofit organization of parents and professionals founded in 1983. (JW)