Research has sought to establish a connection between positive psychological state and physical health and longevity. It has been suggested that persons with a sense of purpose or meaning in life are better able to withstand stress, and enjoy better health. To study the link between a sense of meaning and a sense of physical well-being, 28 college students (8 male and 17 female) completed the Purpose in Life Test, a 20-item test using a 7-point rating scale; and the Life Regard Index, a 24-item self-report measure. Sense of well-being was measured by a self-anchoring scale in which subjects indicated their own well-being on a ten step ladder. Intercorrelations were obtained between the three sets of scores to see if a relationship existed. Scores were also analyzed in relation to age and sex. Although there were some limitations imposed by the testing instruments, tentative results indicated that: (1) there was a positive correlation between a sense of meaning in life and a sense of well-being; (2) students with a higher sense of meaning or purpose had a higher sense of well-being; and (3) among college students, males and females differed significantly in their sense of well-being, with males reporting higher levels of well-being. The findings suggest that a sense of meaning for college students stems from having a purpose or a goal in life, having some kind of philosophical conception of how one should live one's life, and a sense that one is actually living according to this conception of life. These results have implications for counselors who would be in a position to help clients find or extend the meaning in their lives. (JAC)