Since the major causes of accidents are carelessness and a negative or apathetic attitude towards safety, this guide was developed to facilitate safe, stimulating science laboratory activities by providing both general and specific safety information presented in 12 sections. Subject areas considered in these sections include: 1) administrator/teacher/student responsibilities for laboratory safety and legal liability for laboratory accidents (includes extensive guidelines and safety audit checklists); 2) fire; 3) safety equipment and systems; 4) precautions for handling glassware; 5) compressed air, gases, and aerosols; 6) cryogenics (extreme cold); 7) model rocketry and balloons; 8) home chemistry sets; 9) science fairs; 10) chemistry, focusing on handling and storage of chemicals; 11) physics, focusing on the safe use of electrical equipment, radioactive materials, non-ionizing radiation, and lasers; and 12) biology, focusing on microbiological techniques, use of animals, experiments, and poisonous plants, including a list of plants, toxic part(s), and symptoms. A bibliography, list of supplementary resources (films and charts), and three appendices (first aid, wind chill factor, and thunderstorm hazards) are also provided. (JN)