This handbook for school and agency staff presents information on implementing a Career Information System (CIS). Section 1 describes the content, format, and use of CIS information files. Each type of file is discussed individually and sample printouts are included. Section 2 provides materials on QUEST, the twenty-one question process by which the user constructs an individual profile by expressing work/job preferences that are matched to an individualized list of occupations. Section 3 concerns these topics regarding site coordination: standards for CIS use, publicizing CIS, involving faculty, CIS and the guidance process, utilizing paraprofessionals and student aides, career resource centers, CIS statistical package, and troubleshooting. Additional resources provided in section 4 include a glossary and resource lists compiled by Seattle Public Schools, including student reference materials, reference books for students, professional reference, and kits and sets. The final section, amounting to over one-half of the manual, consists of learning activities developed by users or site coordinators for implementing CIS in counseling centers and classrooms. Activities are grouped into career guidance and the subject matter areas of language arts, social studies, science, mathematics, physical education, art, personal finance, business, industrial arts, health, and food services. (YLB)